Cytodiagnosis of Primary Ewing Sarcoma of the Skull: Diagnostic Clues and Difficulties

Ewing sarcoma is a rare primary neoplasm of bone representing approximately 6-8% all malignant tumours. Because its aggressive clinical behaviour and rapid dissemination to other sites, an early accurate diagnosis utmost importance. It shares morphological features with round cell tumors. Common differentials include lymphoblastic lymphoma, neuroblastoma, rhabdomyosarcoma neuroendocrine Due the overlap, critical evaluation cellular details essential. Fine needle aspiration cytology becomes successful diagnostic tool when subtle clues difficulties are considered during diagnosis. Judicious use ancillary techniques will also aid in arriving at We present case seven-year-old boy who presented painful swelling scalp. Aspiration smears were showed atypical small cells. Evaluation along special stains immunohistochemistry block preparation aided rendering sarcoma. The awareness overlapping presentation, morphology immunohistochemical findings help arrive proper Early on samples can timely initiation treatment, thus improve prognosis.